Exceptional mixed-use investment or owner-occupant opportunity in the heart of historic downtown Columbiana! Currently operating as Advanced Podiatry, this well-maintained property offers a highly visible Main Street location just steps from the downtown roundabout and minutes from State Route 11, providing convenient access to Youngstown, Salem, Boardman, and East Liverpool. The property is also near the Firestone Farms shopping, dining, and entertainment district, The Links at Firestone Farms golf course, local restaurants, retail establishments, and professional offices. The main-level commercial office space is thoughtfully designed for medical, professional, or service-based businesses and features a spacious waiting area, intake/reception office, three medical exam rooms, two restrooms (including a handicapped-accessible patient restroom), a kitchenette/break room complete with sink and refrigerator, in-ceiling speaker system throughout, multiple entrances, and a handicapped-accessible ramp for easy client access. The upper level offers additional flexibility with few adjustments necessary to allow for the new owner to live just upstairs from work, or lease as a residential apartment featuring two bedrooms, a kitchen/dining area, and a half bath that could potentially be converted back to a full bath. A separate stairway provides independent access to the basement and exterior, creating those opportunities for owner occupancy, rental income, or additional office expansion. Whether you're seeking a medical office, professional headquarters, investment property, or mixed-use commercial space, this prime downtown Columbiana location combines visibility, accessibility, and versatility in one outstanding package.